Art and Science of Laboratory Medicine

Art and Science of Laboratory Medicine

Friday, April 5, 2013

Treatment outcomes following leukemic transformation in Philadelphia-negative myeloproliferative neoplasms

Leukemic transformation (LT) is a rare but fatal complication of Philadelphia-negative myeloproliferative neoplasms (MPNs) for which optimal treatment strategies are not known. At our center, we have adopted a treatment approach for LT where patients within the transplant age group who have a reasonable fitness level are treated with curative intent and offered induction chemotherapy. Subsequently, those who respond and have a suitable donor are considered for allogeneic hematopoietic cell transplantation (HCT). In this study, we evaluated the clinical outcomes of this treatment approach in 75 patients with LT. 

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Treatment outcomes following leukemic transformation in Philadelphia-negative myeloproliferative neoplasms




















Source: Blood

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