Fecal microbiota transplantation involves instilling gut microbiota from a healthy donor into the diseased gut of a patient who has recurrent or recalcitrant episodes of diarrhea despite antibiotic treatment for C difficile infection. The instillation can be done via nasogastric tube, endoscope, or enema. Donor screening is necessary to prevent transmission of communicable diseases to the recipient. Recently published studies indicate that this procedure is effective for treating recurrent C difficile infection. Randomized clinical trials to assess its efficacy and safety are underway. The field of microbiota therapy is rapidly progressing. More physicians are learning to embrace the concept of fecal microbiota transplantation, and patients are beginning to overcome the “yuck factor” and accept its benefits.
Fecal microbiota transplantation for recurrent C difficile infection: Ready for prime time?
Source: Cleveland Clinical Journal of Medicine
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Art and Science of Laboratory Medicine