C-reactive protein (CRP) enhances IgG-mediated phagocytosis of platelets and patients with immune thrombocytopenia (ITP) have elevated CRP levels, which predicted slower platelet recoveries and bleeding severity.
Binding of antiplatelet antibodies (Ab) to platelets (Plt) triggers platelet oxidation, which also requires the phagocyte NADPH oxidase system. Platelet oxidation exposes oxidized phosphorylcholine (Ox PC) residues from the platelet membrane, providing a Ca2+-dependent binding platform for CRP. CRP subsequently boosts antibody-mediated platelet phagocytosis via phagocytic FcRs.
C-reactive protein boosts antibody-mediated platelet destruction